Aybüke Üretmen*, Caner Demir, Vram Odabaşıoğlu, Abdulhalim Kılıç

Chemical and physical features including stiffness and roughness texture of the biomaterials are important factors for in-vitro and in-vivo cell behaviour. Bone mimetic topography of the biomaterials can enhance the cell adhesion, cell proliferation and differentiation, leading to promoted bone tissue regeneration. In this study, a new technique for transferring the topography of the decellularized cortical bone to the cast metal was described. Imprinting efficiency and accuracy were high, as shown with light microscopy and atomic force microscopy. This method will pave the way for the development of new materials for bone tissue engineering.